莊宜芳老師實驗室
Research
研究團隊致力於探討認知功能與大腦結構隨年齡變化所帶來的改變。
透過大台北地區的城市與郊區中，60歲以上老年族群進行血液、認知功能評估、及腦部核磁共振MRI檢查，我們期許透過瞭解失智症的發生過程，進一步找到預防與治療的對策。
An epistatic interaction between the ɛ4 allele of apolipoprotein E (APOEɛ4) gene and the K-variant of butyrylcholinesterase (BCHE-K) genes has been previously reported to increase risk of Alzheimer's disease (AD). However, these observations were largely from case-control studies with small sample sizes.
Thus, to examine the interaction between APOEɛ4 and BCHE-K on: 1) the risk of incident AD and 2) rates of change in brain volumes and cognitive performance during the preclinical stages of AD in a prospective cohort study.
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Below have more researches about AD and cognitive performance, welcome to read and share your ideas.
NHIRD data (Healthcare utilization patterns)
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